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Yeungnam Univ J Med > Volume 23(2); 2006 > Article
Yeungnam University Journal of Medicine 2006;23(2):143-151.
DOI: https://doi.org/10.12701/yujm.2006.23.2.143    Published online December 31, 2006.
Target Therapy for Colorectal Cancer.
Kyung Hee Lee
Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea. lkhee@med.tu.ac.kr
Abstract
In the past decade, the median duration of survival among patients with advanced colorectal cancer has increased from 12 months to about 18 months, primarily as a results of the introduction of irinotecan and oxaliplatin. Advances in the understanding of the molecular mechanisms underlying the development and progression of cancer have resulted in the discovery of new therapeutic interventions that target specific molecular abnormalities. Their specificity, and therefore their potential to bind preferentially and modify tumor-specific targets, sparing normal tissues and causing fewer side-effects compared to conventional cytotoxic agents, makes them an attractive therapeutic option. The future of this approach for the treatment of solid tumors is promising
Key Words: Target therapy, Colorectal cancer


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