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Yeungnam Univ J Med > Volume 24(1); 2007 > Article
Yeungnam University Journal of Medicine 2007;24(1):85-90.
DOI:    Published online June 30, 2007.
Acute Myeloid Leukemia with t(8;21)(q22;q22) (AML1/ETO) in a Patient with Marked Hypocellularity and Low Blasts Count.
Sung Ho Chun, Hee Soon Cho, Chae Hoon Lee, Kyung Dong Kim, Min Kyoung Kim, Myung Soo Hyun, Soon Il Jung
1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
2Department of Laboratory Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
According to the World Health Organization (WHO) classification system, cases with t(8;21)(q22;q22) should be diagnosed as acute myeloid leukemia (AML) even with a blast count of less than 20 percent in blood or bone marrow. It is an uncommon manifestation, moreover hypocellularity is rarely observed in this subtype of leukemia. Here, we report a case of t(8;21) in a patient with marked hypocellularity of less than 5 percent and a blast count of less than 20 percent. This patient responded relatively well to chemotherapy. An allogeneic bone marrow transplantation was performed with good engraftment . This case suggests that hypocellular AML with a t(8;21) has as good a prognosis as hypercellular AML with t(8;21).
Key Words: Acute myeloid leukemia, t(8, 21)(q22, q22), Hypocellularity
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