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Yeungnam Univ J Med > Volume 28(1); 2011 > Article
Yeungnam University Journal of Medicine 2011;28(1):77-83.
DOI: https://doi.org/10.12701/yujm.2011.28.1.77    Published online June 30, 2011.
Treatment of Hemangiopericytoma-Associated Hypoglycemia with Glucocorticoid Therapy.
Sung Woo Park, Dong Geun Kim, Myung Jin Kim, Hyo Jin Jang, Se Hoon Sohn, Sung Ae Koh, Ha Young Lee, Min Kyoung Kim, Kyoung Hee Lee, Myung Soo Hyun
Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea. hms@med.yu.ac.kr
Abstract
Non-islet cell tumor-induced hypoglycemia (NICTH) is associated with mesenchymal tumor types, including hemangiopericytoma, fibrosarcoma, mesothelioma, and neurofibroma, as well as carcinoma of the liver, adrenal glands, and kidneys. Non-islet cell tumors induce hypoglycemia by overproducing an abnormal form of insulin-like growth factor II (IGF II). Complete removal of the tumor or reduction of the tumor mass is a successful therapeutic strategy in cases of NICTH. However, if the tumor re-grows, curative resection is nearly impossible, and hypoglycemia occurs repeatedly. Glucocorticoids are effective in terms of long-term relief from hypoglycemia through promotion of gluconeogenesis in the liver, tumor suppression, production of 'big'-IGF-II, and correction of the attendant biochemical abnormalities involving the growth hormone (GH)-IGF axis. We found that administration of corticosteroid therapy to a patient suffering from NICTH resulted in improvement of hypoglycemia associated symptoms.
Key Words: Hemangiopericytoma, Hypoglycemia, Prednisolone
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