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Yeungnam Univ J Med > Volume 29(2); 2012 > Article
Yeungnam University Journal of Medicine 2012;29(2):132-135.
DOI: https://doi.org/10.12701/yujm.2012.29.2.132    Published online December 31, 2012.
A Case of Adrenocortical Carcinoma Secreting Cortisol and Aldosterone.
Jiyoon Ha, Min Kyung Kim, Yoon Jin Cha, Seung Kyu Kim, Gi Young Yun, Kwangwon Rhee, Joon Seong Park, Eun Suk Cho, Chul Woo Ahn, Jong Suk Park
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. pjs00@yuhs.ac
2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
3Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
4Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.
Abstract
Adrenocortical carcinomas are rare and frequently aggressive tumors that may be functional (hormone-secreting) and may cause Cushing's syndrome or virilization, or non-functional and manifest as an abdominal mass. This paper reports the case of a 77-year-old woman with cortisol- and aldosterone-secreting adrenal carcinoma. The patient complained of general weakness, a moon face, and weight gain. She also had hypokalemia and hypertension. Her endocrinological data showed excessive aldosterone production and non-suppressible cortisol production in a low-dose dexamethasone suppresion test. Her abdominal CT showed a right adrenal mass. She underwent right adrenalectomy, and her histology revealed the presence of adrenocortical carcinoma. After adrenalectomy, her hypokalemia returned to normal and she is being treated with hydrocortisone.
Key Words: Adrenocortical carcinoma, Aldosterone, Cortisol, Cushing's syndrome, Primary aldosteronism


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