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Yeungnam Univ J Med > Volume 7(1); 1990 > Article
Yeungnam University Journal of Medicine 1990;7(1):151-163.
DOI: https://doi.org/10.12701/yujm.1990.7.1.151    Published online June 30, 1990.
A Clinical and Serologic Study of 21 Cases of Tsutsugamushi Disease Confirmed by Serologic test.
Jong Seon Park, Young Su Kweon, Kwan Ho Lee, Myung Su Hyun, Moon Kwan Chung, Hyun Woo Lee
Abstract
Tsutsugamushi disease is an acute febrile disease caused by Rickettsia tsutsugamushi, and which has been reported with increasing frequency thorough the nation since 1986. We experienced 21 cases of Tsutsugamushi Disease diagnosed with serologic test occurring in Taegu city and Kyungpook province during October-November, 1989. The results of survey are as follow. 1) Of 21 cases, 12 (57%) were males and 9 (43%) were females, and the peak incidence was the 4th decade. 2) The outbreak was in October to November and the peak incidence was in October. 3) The most frequent symptoms were fever and chill (100%), myalgia (95%), headache (90%), Eschar and rash were observed in 18 patients (86%) and the eschar was detected in all over the body, especially thorax (33%) and lower extremity (22%). 4) Laboratory features were SGOT elevation (83%), SGPT elevation (61%), LDH elevation (67%), leukocytosis (38%). 5) Indirect immunofluorescent antibody test was done in 18 patients and the antibody titer was above 1:320 in all patients. 6) The chloramphenicol, tetracycline or doxycycline regimens were very effective and mean duration of defervescence from initiation of therapy was 1.3 days. 7) The complication such as meningitis or shock, was not seen.
Key Words: Tsutsugamushi disease, indirect immunofluorescent antibody test


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