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Yeungnam Univ J Med > Volume 13(2); 1996 > Article
Yeungnam University Journal of Medicine 1996;13(2):243-250.
DOI:    Published online December 31, 1996.
The Effects of Dimethly Sulfoxide and Sodium thiosulfate for the Prevention of Tissue Necrosis due to Extravasation of Mitomycin-C.
Sang Hyun Woo, Byung Cheol Choi, Ki Hyung Kim, Jung Hyun Seul, Tae Eun Jung
Extravasation of toxic chemotherapeutic 'agents cause severe skin ulceration and necrosis which often need secondary surgical intervention. Still, there were not established antidote agent in case of extravasation with mitomycin-c. Dimethyl sulfoxide is known as an effective chemical scavenger of toxic hydroxyl free radical and sodium thiosulfate also was demonstrated significant protector from mitomycin-c induced ulceration by a few experimental studies. Author investigated necrotic area of mitomycin-c injected site and compare to the effectiveness of topical treatment with dimethyl sulfoxide and intradermal injection of sodium thiosulfate according to starting times, forty five mice were divided into 3 groups. Control group(n=5) had no treatment after subcutaneous injection of mitomycin-c. Experimental group I and 11 were 20 mice treated dimethyl sulfoxide and sodium.
Key Words: Extravasation injury, Mitomycn-C, DMSO, STS
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