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Yeungnam Univ J Med > Volume 14(2); 1997 > Article
Yeungnam University Journal of Medicine 1997;14(2):383-392.
DOI: https://doi.org/10.12701/yujm.1997.14.2.383    Published online December 31, 1997.
A Study on the Bone Density in Newborn Infants: Difference of the Bone Mineral Density according to the Gestational Age and the Birth Weight.
Eun Sil Lee, Son Moon Shin, Han Ku Moon, Yong Hoon Park, Kwang Hae Choi
1Department of Pediatrics, College of Medicine, Yeungnam University, Taegu, Korea.
2Department of Pediatrics, Dong Kang Hospital, Ulsan, Korea.
Abstract
To study the differenced of bone mineral density according to the gestational ages and the birth weight and get a reference data for the diagnosis of metabolic bone diseases in the newborn infants, bone mineral densities of the lumbar vertebrae were measured in fifty-three newborn infants bone at Yeungnam University Hospital from March 1, 1995 to February 28, 1997, whose gestational ages were between 28+3 and 41+3 weeks and who had no intrauterine growth retardation, using dual energy X-ray absorptiometry (X-R 26, Norland, USA) within seven days of life. 1. There was no sexual difference in bone mineral density. The bone density increased significantly as gestational age increased from 0.149+/-0.009 g/cm2 at 28-30wks to 0.229+/-0.034 g/cm2 at 39-41wks of gestational age (p<0.05), but there was no significant difference between bone mineral density at 33-34wks and 35-36wks. There was positive linear correlation netween gestational age and bone mineral density (Y=7.5?10-3X-0.082, r=0.7018, p<0.001). 2. The bone mineral density increased significantly as the birth weight increased from 0.158+/-0.020 g/cm2 in 1,000-1,499 g to 0.251+/-0.021 g/cm2 in 3,500-4,000 g of the birth weight (p<0.05), but there was no significant difference between bone mineral densities in 1,000-1,499 g and 1,500-1,999 g of the birth weight. There was positive linear correlation between the birth weight and the bone mineral density (Y=3.9?10-5X+0.093, r=0.7296, p<0.001). There were positive correlations between the bone mineral density and gestational age, and between the bone mineral density and the birth weight. It can be used as a reference data for the further study on the bone mineral metabolism in the newborn infants including preterm babies.
Key Words: Bone density, Dual energy X-ray absorptiometry, DXA, Newborn
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