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Yeungnam Univ J Med > Volume 15(2); 1998 > Article
Yeungnam University Journal of Medicine 1998;15(2):371-380.
DOI: https://doi.org/10.12701/yujm.1998.15.2.371    Published online December 31, 1998.
Two Cases of Systemic Lupus Erythematosus with Cerebrovascular Involvement.
Bong Jun Kim, Eun Young Lee, Young Hoon Hong, Ki Do Park, Young Doo Song, Choong Ki Lee, Young Ran Shim
1Department Of Internal Medicine College Of Medicine, Yeungnam University, Taegue, Korea.
2Department Of Pathology College Of Medicine, Yeungnam University, Taegue, Korea.
Abstract
Systemic lupus erythematosus(SLE) is an autoimmune disease which may affect many different organs and disclose various clinical manifestations. Recently central nervous system(CNS) involvement has been recognized as an increasingly significant contributor to morbidity and mortality of SLE. The clinical manifestations of CNS-lupus are highly variable and range from mild cognitive dysfunction, movement disorder, headache, psychosis to life-threatening stroke and coma. Among the neuropsychiatric disorders encountered in patients with SLE, cerebrovascular disease has been a relatively rare complication. The diagnosis and management of CNS-lupus is difficult because of the lack of useful diagnostic methods. If, cerebrovascular involvement is suspected, then aggressive treatment such as high dose steroid, immunosuppressive therapy, plasma exchange, may be required to reduce high mortality rate. We experienced 2 cases cerebrovascular disease occurring in SLE patients which presented with various neuropsychiatric manifestations. They were diagnosed as CNS-lupus by neuropsychiatric symptoms, brain MRI, and EEG, and showed good response to high dose steroid pulse therapy.
Key Words: CNS-lupus, cerebrovascular disease, SLE


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