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Yeungnam Univ J Med > Volume 18(2); 2001 > Article
Yeungnam University Journal of Medicine 2001;18(2):246-252.
DOI: https://doi.org/10.12701/yujm.2001.18.2.246    Published online December 31, 2001.
Treatment of Henoch-Sch?nlein Purpura with Intravenous Immunoglobulin.
Hyo Seok Chung, Won Duck Kim, Eun Sil Lee, Kwang Hae Choi, Yong Hoon Park, Yong Jin Kim
1Department of Pediatrics College of Medicine, Yeungnam University, Daegu, Korea.
2Department of Pathologe College of Medicine, Yeungnam University, Daegu, Korea.
Abstract
We report the result of a high-dose intravenous immunoglobulin therapy in a Henoch-Sch?nlein purpura patient with severe abdominal pain and nephrotic syndrom who did not respond to methylprednisolone pulse therapy. Kidney bbiopsy showed diffuse mesangial cell proliferative glomerulonephritis with fibrocellular crescent formation in approximately 50% of glomeruli. Mesangium of all glomeruli were strong positive for IgA and C3 antibodies. High-dose intravenous immunoglobulin treatment was introduced and dramatic improvement of gastrointestinal symptom and proteinuria as well as hematuria was noted. Immunoglobulin administration should be considered in Henoch-Schnlein purpura patients with sterois-resistant intractable dastrointestinal manifestation and renal involvenment.
Key Words: Henoch-Schonlein purpura, Nephrotic syndrome, Abdominal pain, Intravenous immunoglobulin


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