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Yeungnam Univ J Med > Volume 19(2); 2002 > Article
Yeungnam University Journal of Medicine 2002;19(2):107-115.
DOI: https://doi.org/10.12701/yujm.2002.19.2.107    Published online December 31, 2002.
Comparison of Ga-67, Tl-201 and Tc-99m MIBI Imaging in Lymphoma Patients.
Kyung Ah Chun, Ihn Ho Cho, Kyu Chang Won, Kyung Hee Lee, Hyung Woo Lee, Myung Soo Hyun, Jae Tae Lee, Kyu Bo Lee
1Department of Nuclear Medicine, College of Medicine, Yeungnam University, Korea. Ihncho@med.yu.ac.kr
2Department of Internal Medicine, College of Medicine, Yeungnam University, Korea.
3Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Abstract
PURPOSE: Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings. MATERIALS AND METHODS: Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma. RESULTS: Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201. CONCLUSION: Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.
Key Words: Tc-99m MIBI, Tl-201, Ga-67, Lymphoma
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