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Yeungnam Univ J Med > Volume 6(2); 1989 > Article
Yeungnam University Journal of Medicine 1989;6(2):13-22.
DOI: https://doi.org/10.12701/yujm.1989.6.2.13    Published online December 31, 1989.
The Effects of Diazepam on the Carbachol Induced Contraction of the Isolated Rat Ileum.
Jung Ok Kim, Oh Cheol Kwon, Jeoung Hee Ha, Kwang Youn Lee, Won Joon Kim
Abstract
To investigate the effect of diazepam on the contractility of the intestinal smooth muscle, longitudinal muscle strip isolated from rat ileum was prepared for myography in isolated organ bath. 1) Basal tone of ileal muscle was reduced by diazepam concentration-dependently. 2) Higher concentrations (30 and 100 microM) of diazepam inhibited (p<0.05, p<0.001) The carbachol-induced contraction in a concentration-dependent manner; but lower concentration of diazepam (10 microM) enhanced (p<0.05). 3) Histamine-induced contraction was inhibited by pretreatment with diazepam in a concentration-dependent manner. 4) Ca⁺⁺-induced tension recovery in calcium-free solution was inhibited in the presence of diazepam concentration-dependently. These results suggest diazepam reduces the contractility of the longitudinal muscle isolated from rat ileum via interference with influx of calcium into the muscle cells.


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