Abstract

We investigated HBV markers in serum and cerebrospinal fluid of 50 subjects with neurologic disorders or other disorders, who visited Dept. of neurology, college of medicine, Yeungnam University, from April-1 to August-31 1994 and were performed cerebrospinal fluid analysis to investigate the detection rate of HBV markers in cerebrospinal fluid and the possibility of neurologic disorders associated with HBV infection. The results were as follows. The positivity of HBsAg and. HBV prevalence rate in serum were 6 (12.04) and 37 (74.0%). Thf, number of patient with HBsAg, only anti-HBV and no markers were 6 (12.0%), 31 (62.0%) and 13 (26.0%), respectively. The positivity of HBsAg and HBV prevalence rate in cerebrospinal fluid were 3 (6%) and 18 (36.0%). The number of patient with HBsAg, only anti-HBV and no markers were 6 (100.0%), 12 (38.7%) and 0 (0.0%) respectively. The number of patient with virus associated diseases (VAD) and non virus associated diseases (NVAD) were 26 (52%) and 24 (48%). The HBV prevalence rate in serum of VAD and NVAD groups were 88.5% and 58.3% (p<0.05). The HBV prevalence rate in CSF of VAD and NVAD groups were 53.8% and 16.7% (p<0.05). The HBV prevalence rate in serum and CSF of VAD and NVAD groups were 60.9% and 28.6%. As a conclusion, the HBV markers in the CSF were partially detected at the presence of the HBV markers in serum. The prevalence rate of HBV in the CSF was increased at the HBsAg positive in the serum and the CSF was significantly increased at the VAD group than the NVAD group

• Keywords: Cerebrospinal Fluid, Hepatitis B virus;