Journal of Yeungnam Medical Science

Original article

Diagnostic performance of F-18 FDG PET or PET/CT for detection of recurrent gastric cancer: a systematic review and meta-analysis: Chang In Choi, Jae Kyun Park, Tae Yong Jeon, Dae-Hwan Kim; J Yeungnam Med Sci. 2023;40(Suppl):S37-S46. Published online August 17, 2023; DOI: https://doi.org/10.12701/jyms.2023.00220

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Abstract PDF: Background
This systematic review and meta-analysis investigated the diagnostic performance of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) or PET/computed tomography (PET/CT) for the detection of disease recurrence after curative resection of gastric cancer.
Methods
The PubMed and Embase databases, from the earliest available date of indexing through November 30, 2019, were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT to detect recurrent disease after gastric cancer surgery.
Results
Across 17 studies (1,732 patients), the pooled sensitivity for F-18 FDG PET or PET/CT was 0.82 (95% confidence interval [CI], 0.74–0.88) with heterogeneity of I2=76.5 (p<0.001), and the specificity was 0.86 (95% CI, 0.78–0.91) with heterogeneity of I2=94.2 (p<0.001). Likelihood ratio (LR) tests gave an overall positive LR of 6.0 (95% CI, 3.6–9.7) and negative LR of 0.2 (95% CI, 0.14–0.31). The pooled diagnostic odds ratio was 29 (95% CI, 13–63). The summary receiver operating characteristic curve indicates that the area under the curve was 0.91 (95% CI, 0.88–0.93).
Conclusion
The current meta-analysis showed good sensitivity and specificity of F-18 FDG PET or PET/CT for detecting recurrent disease after curative resection of gastric cancer despite heterogeneity in ethnicity, recurrence rate, histology, and interpretation method.

Review article

F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the infection of heart: Eunjung Kong; Yeungnam Univ J Med. 2021;38(2):95-106. Published online October 15, 2020; DOI: https://doi.org/10.12701/yujm.2020.00479

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2 Crossref

Infections involving the heart are becoming increasingly common, and a timely diagnosis of utmost importance, despite its challenges. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a recently introduced diagnostic tool in cardiology. This review focuses on the current evidence for the use of FDG PET/CT in the diagnosis of infective endocarditis, cardiac implantable device infection, left ventricular assist device infection, and secondary complications. The author discusses considerations when using FDG PET/CT in routine clinical practice, patient preparation for reducing physiologic myocardial uptake, acquisition of images, and interpretation of PET/CT findings. This review also functions to highlight the need for a standardized acquisition protocol.

Citations

Citations to this article as recorded by

The Role of the 18F-FDG PET/CT in the Management of Patients Suspected of Cardiac Implantable Electronic Devices’ Infection
Antonio Rosario Pisani, Dino Rubini, Corinna Altini, Rossella Ruta, Maria Gazzilli, Angela Sardaro, Francesca Iuele, Nicola Maggialetti, Giuseppe Rubini
Journal of Personalized Medicine.2024; 14(1): 65. CrossRef
The detection of infectious endocarditis may be enhanced by a repeat FDG-PET while maintaining patients on a ketogenic diet
Marine Germaini, Caroline Boursier, François Goehringer, Christine Selton-Suty, Benjamin Lefevre, Véronique Roch, Laetitia Imbert, Marine Claudin, Elodie Chevalier, Pierre-Yves Marie
Journal of Nuclear Cardiology.2022; 29(6): 3256. CrossRef

Review Article

Beta-amyloid imaging in dementia: Kyung Ah Chun; Yeungnam Univ J Med. 2018;35(1):1-6. Published online June 30, 2018; DOI: https://doi.org/10.12701/yujm.2018.35.1.1

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9 Crossref

Abstract PDF

Alzheimer's disease (AD) is a neurodegenerative disorder associated with extracellular plaques, composed of amyloid-beta (Aβ), in the brain. Although the precise mechanism underlying the neurotoxicity of Aβ has not been established, Aβ accumulation is the primary event in a cascade of events that lead to neurofibrillary degeneration and dementia. In particular, the Aβ burden, as assessed by neuroimaging, has proved to be an excellent predictive biomarker. Positron emission tomography, using ligands such as 11C-labeled Pittsburgh Compound B or 18F-labeled tracers, such as 18F-florbetaben, 18F-florbetapir, and 18F-flutemetamol, which bind to Aβ deposits in the brain, has been a valuable technique for visualizing and quantifying the deposition of Aβ throughout the brain in living subjects. Aβ imaging has very high sensitivity for detecting AD pathology. In addition, it can predict the progression from mild cognitive impairment to AD, and contribute to the development of disease-specific therapies.

Citations

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Neurobiology of Aging.2024; 133: 67. CrossRef
Current status of PET tracers for the early diagnosis of Alzheimer's disease
Yuying Li, Tianqing Liu, Qi Zeng, Mengchao Cui
TrAC Trends in Analytical Chemistry.2024; 172: 117546. CrossRef
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Yuying Li, Kaixiang Zhou, Xiaojun Zhang, Hailong Zhao, Xiaoming Wang, Ruilin Dong, Yan Wang, Baian Chen, Xiao-xin Yan, Jiapei Dai, Yanying Sui, Jinming Zhang, Mengchao Cui
Journal of Medicinal Chemistry.2023; 66(7): 4603. CrossRef
Traumatic axonal injury: neuropathological features, postmortem diagnostic methods, and strategies
Qianling Chen, Xuebing Chen, Luyao Xu, Rui Zhang, Zhigang Li, Xia Yue, Dongfang Qiao
Forensic Science, Medicine and Pathology.2022; 18(4): 530. CrossRef
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Yuanyuan Wang, Baichen Xiong, Hongzhi Lin, Qi Li, Hongyu Yang, Yuting Qiao, Qihang Li, Ziwei Xu, Weiping Lyu, Wei Qu, Wenyuan Liu, Yao Chen, Feng Feng, Haopeng Sun
European Journal of Medicinal Chemistry.2022; 244: 114806. CrossRef
Tubulin modifying enzymes as target for the treatment of tau-related diseases
Krzysztof Rogowski, Khaled Hached, Carole Crozet, Siem van der Laan
Pharmacology & Therapeutics.2021; 218: 107681. CrossRef
Imaging Techniques in Alzheimer’s Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring
Wieke M. van Oostveen, Elizabeth C. M. de Lange
International Journal of Molecular Sciences.2021; 22(4): 2110. CrossRef
Imaging Techniques as an Aid in the Early Detection of Cardiac Amyloidosis
M.F. Santarelli, M. Scipioni, D. Genovesi, A. Giorgetti, P. Marzullo, L. Landini
Current Pharmaceutical Design.2021; 27(16): 1878. CrossRef
Protective roles of isoastilbin against Alzheimer's disease via Nrf2‑mediated antioxidation and anti‑apoptosis
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International Journal of Molecular Medicine.2019;[Epub] CrossRef

Case Report

Pulmonary artery sarcoma manifesting as a main pulmonary artery stenosis diagnosed by 18F-FDG PET/CT: Hoonhee Lee, Han Bit Park, Yun Kyung Cho, Jung Min Ahn, Sang Min Lee, Jae Seung Lee, Dae Hee Kim; Yeungnam Univ J Med. 2017;34(2):279-284. Published online December 31, 2017; DOI: https://doi.org/10.12701/yujm.2017.34.2.279

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Abstract PDF: Pulmonary artery sarcoma (PAS) is a rare and fatal disease that often mimics chronic thromboembolic pulmonary hypertension (CTEPH); therefore, diagnosis of PAS is often delayed. Herein, a healthy 74-year-old man was presented with a 4-month history of dyspnea. Chest computed tomography showed wall thickening and stenosis in the main pulmonary artery as well as in both proximal pulmonary arteries. In order to differentiate between unusual CTEPH, vasculitis, and PAS, we performed right heart catheterization and pulmonary angiography. The mean pulmonary arterial pressure was 21 mmHg, and there was severe pulmonary artery stenosis. Thrombi on the pulmonary arterial wall lesions were observed in intravascular ultrasound and optical coherence tomography. Furthermore, the patient had a history of deep vein thrombosis. Therefore, we diagnosed unusual CTEPH. After 6 months of rivaroxaban anticoagulation therapy, a chest X-ray revealed a left lower lobe lung mass, and a positron emission tomography later showed hypermetabolic lesions in the main pulmonary artery wall, in both pulmonary arteries walls, in the lung parenchyma, and in the bones. A biopsy of the right proximal humerus lesion revealed undifferentiated intimal sarcoma. Pulmonary sarcoma is rare, but should be considered when differentially diagnosing main pulmonary artery wall thickening and stenosis. A positron emission tomography may aid in this diagnosis.

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