Journal of Yeungnam Medical Science

Review Article

Beta-amyloid imaging in dementia: Kyung Ah Chun; Yeungnam Univ J Med. 2018;35(1):1-6. Published online June 30, 2018; DOI: https://doi.org/10.12701/yujm.2018.35.1.1

7,537 View
116 Download
9 Crossref

Alzheimer's disease (AD) is a neurodegenerative disorder associated with extracellular plaques, composed of amyloid-beta (Aβ), in the brain. Although the precise mechanism underlying the neurotoxicity of Aβ has not been established, Aβ accumulation is the primary event in a cascade of events that lead to neurofibrillary degeneration and dementia. In particular, the Aβ burden, as assessed by neuroimaging, has proved to be an excellent predictive biomarker. Positron emission tomography, using ligands such as 11C-labeled Pittsburgh Compound B or 18F-labeled tracers, such as 18F-florbetaben, 18F-florbetapir, and 18F-flutemetamol, which bind to Aβ deposits in the brain, has been a valuable technique for visualizing and quantifying the deposition of Aβ throughout the brain in living subjects. Aβ imaging has very high sensitivity for detecting AD pathology. In addition, it can predict the progression from mild cognitive impairment to AD, and contribute to the development of disease-specific therapies.

Citations

Citations to this article as recorded by

Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Neurobiology of Aging.2024; 133: 67. CrossRef
Current status of PET tracers for the early diagnosis of Alzheimer's disease
Yuying Li, Tianqing Liu, Qi Zeng, Mengchao Cui
TrAC Trends in Analytical Chemistry.2024; 172: 117546. CrossRef
Fluorine-18-Labeled Diaryl-azines as Improved β-Amyloid Imaging Tracers: From Bench to First-in-Human Studies
Yuying Li, Kaixiang Zhou, Xiaojun Zhang, Hailong Zhao, Xiaoming Wang, Ruilin Dong, Yan Wang, Baian Chen, Xiao-xin Yan, Jiapei Dai, Yanying Sui, Jinming Zhang, Mengchao Cui
Journal of Medicinal Chemistry.2023; 66(7): 4603. CrossRef
Traumatic axonal injury: neuropathological features, postmortem diagnostic methods, and strategies
Qianling Chen, Xuebing Chen, Luyao Xu, Rui Zhang, Zhigang Li, Xia Yue, Dongfang Qiao
Forensic Science, Medicine and Pathology.2022; 18(4): 530. CrossRef
Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease
Yuanyuan Wang, Baichen Xiong, Hongzhi Lin, Qi Li, Hongyu Yang, Yuting Qiao, Qihang Li, Ziwei Xu, Weiping Lyu, Wei Qu, Wenyuan Liu, Yao Chen, Feng Feng, Haopeng Sun
European Journal of Medicinal Chemistry.2022; 244: 114806. CrossRef
Tubulin modifying enzymes as target for the treatment of tau-related diseases
Krzysztof Rogowski, Khaled Hached, Carole Crozet, Siem van der Laan
Pharmacology & Therapeutics.2021; 218: 107681. CrossRef
Imaging Techniques in Alzheimer’s Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring
Wieke M. van Oostveen, Elizabeth C. M. de Lange
International Journal of Molecular Sciences.2021; 22(4): 2110. CrossRef
Imaging Techniques as an Aid in the Early Detection of Cardiac Amyloidosis
M.F. Santarelli, M. Scipioni, D. Genovesi, A. Giorgetti, P. Marzullo, L. Landini
Current Pharmaceutical Design.2021; 27(16): 1878. CrossRef
Protective roles of isoastilbin against Alzheimer's disease via Nrf2‑mediated antioxidation and anti‑apoptosis
Hong Yu, Bo Yuan, Qiubo Chu, Chunyue Wang, Hui Bi
International Journal of Molecular Medicine.2019;[Epub] CrossRef

First
Prev
Page of 1
Next
Last

Search