Journal of Yeungnam Medical Science

Volume 5(2); December 1988

Reviews

Pancreatic polypeptide family-PP, NPY, PYY.: Kwang Youn Lee; Yeungnam Univ J Med. 1988;5(2):1-8. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.1

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Abstract PDF: No abstract available.

Liver Disease in Pregnancy.: Sung Ho Lee, Min Whan Koh; Yeungnam Univ J Med. 1988;5(2):9-24. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.9

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Abstract PDF: No abstract available.

Original Articles

Histologic Changes of Rabbit Skin Induced by Progressive Tissue Expansion.: Jae Ho Jeong, Ki Yeol Kim, See Ho Choi, Jung Hyun Seul; Yeungnam Univ J Med. 1988;5(2):25-30. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.25

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Abstract PDF: Soft-tissue expansion is a new surgical technique of providing donor tissue in modern reconstructive surgery. This technique provides a quantity of tissue of similar color, texture, and hair-bearing qualities for reconstruction of adjacent defects. It is known that the expanded skin shows several constant histologic changes including the increase in collagen fibers and vascularity within dermis, and thinning of subcutaneous tissue and dermis. In this study, the author observed serial histologic changes of rabbit skin induced by progressive tissue expansion up to excessive expansion of 6 times. The results are as follows: 1. Changes in the thickness of the epidermis was minimal until 3 times of expansion, but slight thinning was observed at excessive expansion state. 2. The thickness of the dermis was progressively decreased, and collagen fibers in the dermis was rapidly increased in early phase of expansion. 3. The vascularity in the dermis was also progressively increased. 4. The skin appendages showed no structural changes even in excessive expansion. 5. The panniculus carnosus showed no atrophic changes and the thickness was maintained in excessive expansion.

A Study on ARC Therapy of 18MeV Linear Accelerator.: Seong Kyu Kim, Sei One Shin, Myung Se Kim; Yeungnam Univ J Med. 1988;5(2):31-36. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.31

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Abstract PDF: In recent years there has been a growing interest in all forms of rotational therapy, and many different types of therapy machines designed for this kind of treatment have become available. To the medical radiation physicist, the dosimetry of rotation therapy has presented a number of interesting problems, and much useful work has been published on the basic date of dose distribution and dosage calculation. The setting dose for ARC therapy were obtained by computer calculation and measurement with cylindrical phantom. Authors compared computer calculation with measured value. And in ARC therapy, the region of maximum dose in shifted from the tumor center. The extent of shift was analyzed by isodose distribution for ARC therapy techniques.

Homogeneity of Phospholipase C of Bovine Uterus and Seminal Vesicle Compared with Brain Isozymes.: Jung Hye Kim, Ki Yung Lee, Sue Goo Rhee; Yeungnam Univ J Med. 1988;5(2):37-45. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.37

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Abstract PDF: Phosphoinositide-specific Phospholipase C (PI-PLC) is a second messenger of signal transducer on cell membrane. In the previous study, PLC of bovine brain has been purified three isozymes. In this paper, uterus and seminal vesicle have been purified. Two peaks of PI-PLC activity were resolved when bovine uterus and seminal vesicle proteins were chromatographed on a DEAE and phenyl TSK 5PW HPLC column. Each two peak was compared with PI-PLC I, II and III from bovine brain and we got the retention time on HPLC. The peak fractions with PLC activity were tested homogeneity with brain PLC monoclonal antibodies (Mab). Mab-labeled affigels were bounded in the range of 73.8%~97.5% with PLC I, II and III. Homogeneity of fractions were revealed that DEAE F-1 and phenyl F-1-I were highest level of PLC III in uterus and seminal vesicle and DEAE F-2 and phenyl F-2-I were mixed PLC I and II.

Diagnostic Value of the Intradermal Test for the Infection with Clonorchis sinensis.: Jong Ho Kim, Bong Yung Yun, Heon Ju Lee, Hyun Woo Lee; Yeungnam Univ J Med. 1988;5(2):47-52. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.47

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Abstract PDF: The intradermal (ID) test has been widely used in Korea and several reports about the results of the ID test are known. We examined the egg of Clonorchis sinensis (C.s.) by ID test in 443, stool's egg-counting technique in 79 and direct smear (cellophane thick smear technique) in 1204 subjects. The results are as follows: 1. The positive rate of C.s. was 3.8% out of 1304 persons. 2. The sensitivity of ID test was 82.1% out of 39 persons and the specificity was 64.6% out of 404 persons. 3. The false positive of ID test was 35.4% out of 404 persons and, the false negative was 17.9% out of 39 persons. Intradermal test is a rapid, sensitive and useful supplementary diagnostic tool for the detection of Clonorchiasis infection and must be used as screening test with direct smear of stool but cross reaction with other helminth infections and moderate false reaction are the main disadvantages in its practical application.

Comparison of KOH Positivity According to Sites of the Ring-shaped Dermatophytotic Skin Lesion.: Dong Hoon Shin, Jong Soo Choi, Ki Hong Kim; Yeungnam Univ J Med. 1988;5(2):53-58. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.53

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Abstract PDF: KOH examination is a simple, rapid and diagnostic procedure to confirm dermatophytic infections. It is important to select a proper examination site of the lesion. To determinate the proper examination site of the lesion, mycologic studies were done with multiple specimens collected from the center, margin and out of margin of the ring-shaped dermatophytic skin lesion on the 58 patients. The results were as follows. Positive rate of KOH wet smear was 94.8% at the center and 100% at the margin of the lesions, 22.4% at the 1 cm and 5.2% at the 2 cm out of the lesions. The more hyphae were found in the lesion, the more hyphae were found out of the lesion. Culture was done on the Sabouraud's glucose agar from the highest KOH positive area and the positive culture was 48 strains (82.8%) of 58 patients. These findings suggested that the ring-shaped active margin was the best site to examine mycologic studies.

Effects of Strontium on Norepinephrine Induced Positive Inotropic Effect of Isolated Perfused Rat Hearts.: Oh Cheol Kwon, Kwang Youn Lee; Yeungnam Univ J Med. 1988;5(2):59-69. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.59

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Abstract PDF: This study was designed to investigate the effect of substitution of strontium for calcium on mechanical activity in isolated perfused spontaneously beating rat hearts. The mechanical activity of the hearts of Langendorff's preparation in conditions of low calcium and strontium-substitution for calcium was compared. The effect of norepinephrine and verapamil were also observed in those conditions. The results were as follows: 1. In low calcium, the mechanical activity of the heart preparation was significantly reduced, but when the equimolar strontium was substituted for the reduced calcium, the activity was kept at similar level to the normal condition. 2. When equimolar strontium was substituted for the total calcium in perfusate, the heart preparation stopped its beating, and it was not restored in spite of reperfusion with normal calcium perfusate. 3. Norepinephrine-induced positive inotropic effect was inhibited in low-calcium condition especially with low concentration of norepinephrine, but not in strontium-substitution for calcium. 4. Verapamil reduced the activity of the heart both in low-calcium and strontium-substitution as well as in normal calcium conditions. From above results, it was concluded that strontium served as a substitute of calcium in maintaining mechanical activity and in responsiveness to norepinephrine, and the influx of strontium through cell membrane is inhibited by verapamil as the influx of calcium.

The Effect of Mouth Breathing Due to Nasopharyngeal Obstruction by Adenoids on the Tongue, Mandible and Hyoid Bone Position.: Hee Kyoung Lee; Yeungnam Univ J Med. 1988;5(2):71-77. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.71

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Abstract PDF: This study was made to investigate the influence of mouth breathing to tongue, mandible and hyoid bone position. It has been clinically suggested that the mouth breathing is induced by the respiratory dysfunction of nasopharyngeal airway causing by the Adenoids. The author used the 50 children, who were the nasal breathes with normal occlusion as the control group, and 50 children, who were mouth breathers with Adenoid as the experimental group. Results were as following: 1. In experimental group, the tongue was positioned more anterior and lower than that of the normal children. 2. In experimental group, the mandible was positioned more lower than that of the normal children. 3. In experimental group, the hyoid bone was positioned more anterior and lower than that of the normal children.

The Effect of Exercise on the Conversion Rate of Ingested Glucose to Glycogen in the Hindlimb Skeletal Muscles in Rats.: Kyung Hwa Jung, Jong Yeon Kim, Yong Woon Kim, Suck Kang Lee; Yeungnam Univ J Med. 1988;5(2):79-86. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.79

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Abstract PDF: In the present study the effect of exercise on the conversion rate of ingested glucose to glycogen in the different types of hindlimb skeletal muscles in Sprague-Dawley male rats was studied. The amounts of synthetized glycogen from ingested glucose of fast-twitch white (WV), fast-twitch red (RV), mixed type of fast-twitch white and red (EDL), and slow-twitch (SOL) muscles were determined at 30 and 90 min. after ingestion of 25% glucose solution which contained 14C-glucose(2 ml(luCi)/100gm B.W.) in control and exercise loaded rats. The result was summarized as follows: The about 55% at 30 min. and 70% at 90 min. after glucose ingestion were absorbed from gastrointestinal tract. This result shows no effects of exercise on absorption rate from gastrointestinal tract. The amount of synthetized glycogen of SOL from ingested glucose at 30 and 90 min. after glucose ingestion were highest, whether WV were lowest in hindlimb skeletal muscles in control and exercise loaded rats. In the exercise loaded rats, the amounts of synthetized glycogen of SOL, RV, and EDL at 90 min. after glucose ingestion was much higher than control rats, but not different in WV between exercise-loaded and control rats. At 30 min. after glucose ingestion, only SOL of exercise loaded rats was higher than control rats. In the control rat, the synthesis of glycogen was almost completed during initial 30 minutes. On the other hand, in the exercise loaded rat, except WV was opposite result of control rats, i.e., amounts of synthetized glycogen were major during late period. The amount of synthetized glycogen of liver at 30 and 90 min. after glucose ingestion in exercise loaded rats was higher than control rats. The rate of glycogen synthesis in control and exercise loaded rats were higher between 30-90 minute than initial 30 minutes.

Clinical Study of CT-diagnosed Olivopontocerebellar Atrophies.: Mee Yeong Park, Khyoung Yhun O, Jung Sang Hah, Yeung Ju Byun, Choong Suh Park; Yeungnam Univ J Med. 1988;5(2):87-93. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.87

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Abstract PDF: The diagnosis of OPCA could be made clinically with important aid of brain CT scanning, although the definite and conclusive diagnosis only by postmortem pathological determination. We reviewed, clinically and with brain CT examination, 12 cases of patients with OPCA who were admitted to the Yeungnam University Hospital for a recent 5 years. The result were as following: 1. The distribution of age is from 49 to 72, mainly 50 to 60. Man is more frequent than women at the 4.5 times. 2. The interval period from Sx. Onset to diagnosis is 1 year to 6 years. 3. The usual initial Sxs. Were dizziness (58%), ataxia (33%), and other less frequent Sxs. Were weakness of low extremities, dysarthria, headache and urinary incontinence. The clinical manifestations at the initial diagnosis were cerebellar disturbance (100%), dysarthria (83%), and increased deep tendon reflexes (58%). 4. The results of brain CT finding are like this: the width of cerebellar sulci is more than 1mm, other 4 cases more than 2mm. the width of cerebellar pontine cistern of the patient if usually 3 to 4mm, other 2 cases extended to the 5 mm. the A. P and lateral lengths of 4th. ventricle is 4 mm and 4 to 8 mm respectively. 6 cases of whole patients show coincidentally cerebral atrophy.

The Bronchodilatory Effect of Ipratropium Bromide on Bronchial Asthma.: Jae Hee Ahn, Tae Nyeon Kim, Young Hyeun Lee, Jae Chun Chung, Hyun Woo Lee; Yeungnam Univ J Med. 1988;5(2):95-100. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.95

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Abstract PDF: Ipratropium bromide (IP) is a new anticholinergic bronchodilator. To evaluate its effect on bronchial asthma which is still unknown in Korea, a double blind and randomized study was done on all patients of bronchial asthma who visit out-patients clinic of out department from June to September 197 and showed 75 to 100% of FEV1/FVC ratio on prebronchodilator spirometry (pre BD). The selected patients were given 2 puffs of Fenoterol (FE) or Ipratropium inhalator blindly and Spirometry. The repeated results are: 1. In both FE and IP groups, there was a significant bronchodilatory effect on 5 and 60 minutes after administration. 2. One 5 minutes, effect of FE was significantly greater than IP (FVC p<0.05, FEV1 p<0.01). 3. One 60 minutes, effect of IP was slightly less than FE but statistically non-significant. On the basis of above results, we concluded that onset of effect of IP is slower than FE, but its effect is significant and nearly comparable to FE.

Clinical Study of 459 Cases Cardiovascular Surgery.: Han Young Ryu, Tae Eun Jung, Yee Tae Park, Sung Sae Han; Yeungnam Univ J Med. 1988;5(2):101-110. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.101

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Abstract PDF: Between April, 1984 and September 1988, 459 patients underwent cardiovascular surgery at the Yeungnam University Hospital. Of these, 355 cases were open heart surgeries and 104 cases were non-open heart surgeries. There were 237 patients of acyanotic congenital cardiac anomalies, 40 patients of cyanotic congenital cardiac anomalies, and 85 patients of acquired heart diseases. The sex ratio of cardiovascular diseases was represented as 1:1.3 in male and female. The age distribution was ranged from 1 day to 65 years old. The common congenital cardiovascular anomalies were ventricular septal defect (38.7%), patent ductus arteriosus (25.5%), atrial septal defect (20.7%), Tetralogy of Fallot (8.3%), and pulmonary stenosis (2.4%) in order of frequency. Among 87 acquired cardiovascular diseases, 81 patients underwent operation for cardiac valvular lesions, 51 patients had mitral valve replacement and 13 patients had aortic valve replacement and 17 patients had double valve replacement. The overall mortality of cardiovascular surgery was 3.3% and mortality of open heart surgery was 3.9%.

Effects of Dimethyl Sulfoxide on the Differentiation of Myocardial and Endothelial Cells.: Dong Hyup Lee, Yee Tae Park, Sung Sae Han, Yung Chang Lee; Yeungnam Univ J Med. 1988;5(2):111-119. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.111

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Abstract PDF: To elucidate the effects of dimethyl sulfoxide on of myocardial and endothelial cells in culture, the cells were exposed to 10% dimethyl sulfoxide in culture medium for 1 hour at 48 hours after cell isolation. The general morphology and the cytochemical reaction of marker enzymes for mitochondria and Golgi complexes were investigated. The results were summarized as follows 1. DMSO induced elongation and narrowing of the cells and increase of mitochondrial reaction in myocardial cells. 2. DMSO induced destruction and disruption of myofibrils in myocardial cells resulting in increase of contractile activities. 3. In the endothelial cells, DMSO suppressed proliferative activities but thiamine pyrophosphatase reactions were enhanced indicating increase of Golgi complex activity. 4. DMSO seemed to hamper with the adhesiveness and motility of the endothelial cells causing the decrease of the number of cells in vitro.

Clinical and Histopathological Studies on Carcinoma of the Uterine Cervix in Taegu.: Joon Hyuk Choi, Won Hee Choi, Suk Jae Hong, Tae Sook Lee; Yeungnam Univ J Med. 1988;5(2):121-128. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.121

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Abstract PDF: Clinical and histopathological studies were made on 202 cases of malignancy of cervix, that were visited to the Department of Obstetrics and Gynecology, Yeungnam University Hospital, during 5 years from 1983 to 1987. The results were summarized as follows. 1. Malignancies of the uterine cervix were 10% of total female malignancies. 2. Among 202 cases, 195 cases (96.5%) were squamous cell carcinoma, in which 60 cases (30.0%) of carcinoma in situ, 9 cases (4%) of microinvasive, and 126 cases (62.5%) of invasive carcinoma were included. 3. The average age of the patients with squamous cell carcinoma was 49.4 years old; In case of carcinoma in situ, it was 43.8, microinvasive, 40.0, invasive 52.1 years old. 4. Clinical symptoms of the patient with squamous cell carcinoma in order of frequency were as follows; vaginal bleeding (47.5%), abnormal cytology (15.4%), and abnormal vaginal discharge (9.4%). 5. Duration of the chief complaints was most commonly less than 6 months (73.2%), and the average duration was 3.8 months. 6. The most common age of marriage was between 19 to 22 years old (46.5%). The average was 21.5 years old. 7. The gravity was 51.5% in 5-8 times, and average 6.2 times. The parity was 61.9% in 1-4 times, and average 3.9 times. 8. The subdivision of 126 cases of invasive carcinoma was made according to FIGO stage classification, stage I, 40 cases (31.8%), stage II, 54 cases(42.9%), stage III, 11 cases (8.7%), and stage IV, 8 cases (6.3%). 9. The histologic subtypes of invasive squamous cell carcinoma were distributed as follows; large cell keratinizing type, 25 cases (19.8%), large cell nonkeratinizing type, 101 cases (80.2%). 10. In the cytologic diagnosis, class I was 2 cases (1.9%), class II was 16 cases (15.1%), class III was 33 cases (31.1%), class IV was 31 cases (29.3%), class V was 24 cases (24.6%). 11. The frequency of lymph node metastasis was 7.5% in stage I, and 11.1% in stage II.

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